mProX™ Human CACNA1B Stable Cell Line

Product Information

Target Protein

CACNA1B

Target Family

Voltage Gated Calcium Channel

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research

Related Diseases

Neurodevelopmental Disorder With Seizures; Nonepileptic Hyperkinetic Movements; Non-Specific Early-Onset Epileptic Encephalopathy

Gene ID

774

UniProt ID

Q00975

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The presynaptic neuronal voltage-dependent calcium channel CaV2.2, which is distributed throughout the central nervous system and in numerous brain areas, has a pore-forming subunit that is encoded by the CACNA1B gene. Many excitable cells include multisubunit complexes called voltage-dependent Ca(2+) channels that control calcium entry. An at least 5-gene family encodes the alpha-1 subunit, which creates the hole through which calcium enters the cell. The cerebral cortex and white matter, hippocampus, basal ganglia, and cerebellum are only a few of the areas of the human brain where CACNA1B is expressed. As Cav2.2 channels are replaced by Cav2.1 channels in mature synapses within the thalamus, cerebellum, and auditory brainstem, it is believed that CACNA1B expression is essential for neurotransmission in the early postnatal period. The customized CACNA1B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Shirley (Verified Customer)

How does CACNA1B relate to apoptosis? Jan 27 2020

chat Sherry Smith (Creative Biolabs Scientific Support)

CACNA1B is associated with the regulation of apoptosis-related proteins, which play a crucial role in cell survival and death. Jan 27 2020

chat Linda (Verified Customer)

What is the role of CACNA1B in lung adenocarcinoma? Feb 21 2020

chat Sherry Smith (Creative Biolabs Scientific Support)

CACNA1B is involved in the immune response and has been positively correlated with the infiltration level of most immune cells in lung adenocarcinoma. It may serve as a significant prognostic biomarker and a potential drug target. Feb 21 2020

Published Data

Fig.1 e37a-Cacna1b splice isoforms are expressed in mPFC, vHPC and AMY.

An agarose gel electrophoresis of the undigested PCR products of the RT samples from mPFC, vHPC, and AMY is shown in the representative image. Every RNA sample had negative controls that lacked reverse transcriptase.

Ref: Bunda, Alexandra, et al. "Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli." Molecular brain 12.1 (2019): 1-14.

Pubmed: 31630675

DOI: 10.1186/s13041-019-0500-1

Research Highlights

A gain-of-function contributing to the observed hyperexcitability feature of this distinct myoclonus-dystonia-like disease linked to cardiac arrhythmias could be explained by functional alterations.
Groen, Justus L., et al. "CACNA1B mutation is linked to unique myoclonus-dystonia syndrome." Human molecular genetics 24.4 (2015): 987-993.
Pubmed: 25296916 DOI: 10.1093/hmg/ddu513

The primary goal of this study was to investigate the role that Calcium Voltage-Gated Channel Subunit Alpha1 B (CACNA1B) plays in the development of breast cancer and the associated system.
Jin, Yong-Mei, et al. "CACNA1B facilitates breast cancer cell growth and migration by regulating cyclin D1 and EMT: the implication of CACNA1B in breast cancer." Journal of Receptors and Signal Transduction 42.1 (2022): 1-8.
Pubmed: 33100116 DOI: 10.1080/10799893.2020.1837871