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    mProX™ Human CACNA1B Stable Cell Line

    [CAT#: S01YF-1123-KX12]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    CACNA1B
    Target Family
    Voltage Gated Calcium Channel
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Neurodevelopmental Disorder With Seizures; Nonepileptic Hyperkinetic Movements; Non-Specific Early-Onset Epileptic Encephalopathy
    Gene ID
    774
    UniProt ID
    Q00975

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The presynaptic neuronal voltage-dependent calcium channel CaV2.2, which is distributed throughout the central nervous system and in numerous brain areas, has a pore-forming subunit that is encoded by the CACNA1B gene. Many excitable cells include multisubunit complexes called voltage-dependent Ca(2+) channels that control calcium entry. An at least 5-gene family encodes the alpha-1 subunit, which creates the hole through which calcium enters the cell. The cerebral cortex and white matter, hippocampus, basal ganglia, and cerebellum are only a few of the areas of the human brain where CACNA1B is expressed. As Cav2.2 channels are replaced by Cav2.1 channels in mature synapses within the thalamus, cerebellum, and auditory brainstem, it is believed that CACNA1B expression is essential for neurotransmission in the early postnatal period. The customized CACNA1B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

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    FAQ

    chat Shirley (Verified Customer)

    How does CACNA1B relate to apoptosis? Jan 27 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    CACNA1B is associated with the regulation of apoptosis-related proteins, which play a crucial role in cell survival and death. Jan 27 2020

    chat Linda (Verified Customer)

    What is the role of CACNA1B in lung adenocarcinoma? Feb 21 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    CACNA1B is involved in the immune response and has been positively correlated with the infiltration level of most immune cells in lung adenocarcinoma. It may serve as a significant prognostic biomarker and a potential drug target. Feb 21 2020

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    • mProX™ Human CACNA1B Stable Cell Line (CAT#: S01YF-1123-KX12)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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