mProX™ Human CACNA1A Stable Cell Line

Product Information

Target Protein

CACNA1A

Target Family

Voltage Gated Calcium Channel

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research

Related Diseases

Timothy Syndrome; Long Qt Syndrome

Gene ID

773

UniProt ID

O00555

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The CACNA1A gene is a member of a group of genes that give instructions on how to create calcium channels. The CaV2.1 calcium channel's alpha-1 subunit can be produced using instructions from the CACNA1A gene. In the brain, CaV2.1 channels are crucial for facilitating communication between nerve cells. These channels are particularly prevalent in neurons known as granule cells and Purkinje cells. The area of the brain responsible for movement coordination contains these neurons. Neurotransmitters, which are molecules that transfer messages from one neuron to another, are released under regulation in part by CaV2.1 channels. CaV2.1 channels may potentially play a role in the longevity of neurons and their capacity to evolve and adapt over time, according to research. The customized CACNA1A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Kimberly (Verified Customer)

Are there any known diseases or conditions associated with CACNA1A? Sep 16 2022

chat Sherry Smith (Creative Biolabs Scientific Support)

CACNA1A has been implicated in various conditions, but specific diseases or conditions directly associated with ADRA2C in the context of cell lines were not identified in the current dataset. Sep 16 2022

chat Gary (Verified Customer)

What is the significance of CACNA1A in scientific research? Mar 12 2022

chat Sherry Smith (Creative Biolabs Scientific Support)

CACNA1A has been studied in various contexts, like timothy syndrome. Mar 12 2022

Published Data

Fig.1 Structure and expression of the Cacna1a gene in tottering-6j mice.

Cacna1a gene expression analysis using Western blot and RT-PCR in 6j/6j and +/+ mice. The Cacna1a gene's representative protein expression pattern is displayed. The total RNA loading was controlled by using GAPDH.

Ref: Li, Weidong, et al. "New ataxic tottering-6j mouse allele containing a Cacna1a gene mutation." (2012): e44230.

Pubmed: 22952933

DOI: 10.1371/journal.pone.0044230

Research Highlights

Type 2 episodic ataxia, type 1 familial hemiplegic migraine, and type 6 spinocerebellar ataxia are usually associated with variations in CACNA1A. With time, CACNA1A has been linked to a wider range of phenotypes.
Hommersom, Marina P., et al. "The complexities of CACNA1A in clinical neurogenetics." Journal of Neurology (2021): 1-15.
Pubmed: 34806130 DOI: 10.1007/s00415-021-10897-9

The neuropsychiatric forms of episodic CACNA1A abnormalities are frequently observed. If there is a positive family history and an otherwise unexplained developmental delay, CACNA1A mutations should be taken into consideration in the differential diagnosis.
Indelicato, E., et al. "The neuropsychiatric phenotype in CACNA1A mutations: a retrospective single center study and review of the literature." European journal of neurology 26.1 (2019): 66-e7.
Pubmed: 30063100 DOI: 10.1111/ene.13765