mProX™ Human C5AR1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The C5AR1 gene, encoding the C5a receptor 1, has been extensively studied for its role in various physiological and pathological processes. This receptor is a part of the complement system and is known to play a crucial role in inflammation and immune responses. Recent research has shown that C5AR1 is involved in ischemic stroke, where the Guhong Injection was found to prevent ischemic stroke-induced neuro-inflammation through the regulation of C5AR1. Another study highlighted the association of C5AR1 with COVID-19 inflammation, suggesting that the C5a-C5aR1 axis could be a potential therapeutic target for patients with COVID-19. Furthermore, the C5AR1 gene has been implicated in chemotherapy-induced peripheral neuropathy and hypersensitivity reactions, where paclitaxel was found to bind and activate C5aR1. Additionally, the C5AR1 gene has been associated with breast cancer glycolysis, where C5aR1-positive neutrophils were found to promote glycolysis through m6A methylation of ENO1. In summary, the C5AR1 gene has a multifaceted role in scientific research, with implications in neuro-inflammatory conditions, viral infections, and cancer metabolism.