mProX™ Human BDKRB2 Stable Cell Line

Sychev IV, et al. "Pharmacogenetic markers of development of angioneurotic edema as a secondary side ." The International journal of risk & safety in medicine, 2023.
Angioneurotic edema is a dangerous complication that can occur in patients undergoing therapy with angiotensin-converting enzyme inhibitors (ACEIs). Despite available data, there is still insufficient research on the clinical and genetic factors that may predict the development of angioedema, highlighting the importance of further study. This research aimed to identify pharmacogenetic predictors of angioedema as a secondary side effect of enalapril in patients with essential arterial hypertension. A total of 111 individuals were enrolled and divided into a study group (with angioedema) and a control group (without adverse drug reaction), and underwent pharmacogenetic testing. The results showed that the genotypes AA rs2306283 of gene SLCO1B1, TT rs4459610 of gene ACE, and CC rs1799722 of gene BDKRB2 were associated with the development of angioneurotic edema in patients. These findings suggest a need for larger studies to further investigate these genetic predictors.
Pubmed: 37742663   DOI: 10.3233/JRS-230006

Bhebhe CN, et al. "K(V)7 but not dual small and intermediate K(Ca) channel openers inhibit the ." American journal of physiology. Gastrointestinal and liver physiology, 2023.
Numerous subtypes of central and peripheral neurons are regulated by small and intermediate conductance Ca(2+)-activated K(+) channels (SK and IK, respectively) in terms of neuronal excitability. Coexpression of transcripts encoding SK channel subunits and the closely related IK subunit is observed in the soma of colonic afferent neurons, alongside receptors for ATP and bradykinin, highlighting the potential of these channels as drug targets for abdominal pain in gastrointestinal diseases. However, in experiments involving the application of ATP, bradykinin, or noxious ramp colon distention, pretreatment with the dual SK/IK channel opener SKA-31 did not have any effect on the colonic afferent response. In electrophysiological experiments, inhibition of SK or IK channels with apamin or TRAM-34, respectively, did not alter spontaneous baseline afferent activity, indicating a lack of tonic activity in these channels. Conversely, SKA-31 was found to abolish ongoing peristaltic activity in the colon ex vivo, while treatment with the K(V)7 channel opener retigabine was shown to reduce the colonic afferent response to all stimuli. Overall, these results suggest a potential analgesic role for K(V)7 channel openers, but not SK/IK channel openers, in the treatment of abdominal pain.
Pubmed: 37667839   DOI: 10.1152/ajpgi.00141.2023