BDKRB2
The bradykinin receptor is encoded by this gene. The 9 aa bradykinin peptide causes a variety of reactions, such as vasodilation, edema, smooth muscle spasm, and activation of pain fibers. Bradykinin binds to its kinin receptors, B1 and B2, and is released when pathophysiologic circumstances like trauma and inflammation activate it. The phosphatidylinositol-calcium second messenger pathway is stimulated by the association of the B2 receptor with G proteins. Hereditary angioedema and brain edema are two conditions linked to BDKRB2. Its associated pathways include Class A/1 and GPCR downstream signaling (Rhodopsin-like receptors). This gene has annotations for G protein-coupled receptor function and protease binding in the Gene Ontology (GO) database.
Full Name | Bradykinin receptor B2 |
Gene ID | Human: 624 Mouse: 12062 Rat: 25245 Monkey: 703698 |
UniProt ID | Human: P30411 Mouse: P32299 Rat: P25023 Monkey: A0A2K6SY98 |
Alternative Names | B2R; BK2; BK-2; BKR2; BRB2; BK-2 receptor; B2 bradykinin receptor; BDKRB2; Bradykinin receptor B2 |
Product List
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Rat Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Rhesus monkey Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Family Target Protein Species: Human Host Cell Type: SiHa;HeLa;CHO-K1;HEK293
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Dog Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Guinea pig Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin receptor Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1/Gα15 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Family Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Mouse Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BDKRB2 Target Family: Bradykinin Target Protein Species: Rabbit Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay