mProX™ Human AVPR2 Stable Cell Line
[CAT#: S01YF-0923-KX57]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
AVPR2
Target Family
Vasopressin and Oxytocin Family
Target Protein Species
Human
Host Cell Type
MDCK; CHO-K1; HEK293
Target Classification
GPCR Cell Lines
Target Research Area
CNS Research; Cardiovascular Research; Digestive and Renal Research
Related Diseases
Nephrogenic Syndrome Of Inappropriate Antidiuresis; Diabetes Insipidus; Nephrogenic; X-Linked
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The G protein-coupled receptor (GPCR) superfamily includes the arginine vasopressin receptor 2 (AVPR2), which has seven transmembrane domains. The distal convoluted tubules and collecting ducts are the main locations where this molecule is expressed. Its primary role in maintaining water balance in the body and concentrating urine under physiological settings is to activate mechanisms in response to the pituitary hormone arginine pressor (AVP). The most common cause of congenital nephrogenic diabetes insipidus is mutations in this gene. Numerous malignancies, including osteosarcoma, renal cell carcinoma, breast cancer, pancreatic cancer, colorectal cancer, and small cell lung cancer, have been identified to express AVPR2. Clear cell renal carcinoma cell line proliferation is encouraged by AVPR2 activation, which is linked to tumor grade. The customized AVPR2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Astrid
The Human AVPR2 Stable Cell Line meets my requirement.
Feb 17 2023
Verified Customer
Arno
I customized the mouse AVPR2 cell line for my research.
Dec 02 2022
Verified Customer
FAQ
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