mProX™ Human APLNR Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 APLNR was involved in ATRA-induced cell cycle arrest.
The 5-8F and HNE-1 cell lines underwent transfection with control, APLNR, shRNA1#, and shRNA3# vectors, then received ARTA treatment (10μm and 400 nM) for six days. Flow cytometry was employed to assess cell cycle distribution. In the case of 5-8F cells, transfection encompassed control, shRNA1#, and shRNA3#, followed by ATRA treatment. HNE-1 cells were subjected to analogous treatment as 5-8F cells. The resulting bar chart illustrates cell cycle distribution for both 5-8F and HNE-1 cell lines.
Ref: Liu, Yi, et al. "APLNR is involved in ATRA-induced growth inhibition of nasopharyngeal carcinoma and may suppress EMT through PI3K-Akt-mTOR signaling." The FASEB Journal 33.11 (2019): 11959-11972.
Pubmed: 31408612
DOI: 10.1096/fj.201802416RR
Research Highlights
Mohan K, et al. "Age-Associated Changes in Endothelial Transcriptome and Epigenetic Landscapes ." Journal of the American Heart Association, 2023.
In this study, the authors aimed to investigate the mechanisms underlying the age-related development of stroke, a leading cause of death and disability worldwide. They focused on the role of cerebral endothelial cells (ECs), which make up the blood-brain barrier, in maintaining vascular integrity and preventing stroke. Through gene expression analysis and exploration of chromatin structure and DNA methylation, the authors identified age-related changes in cerebral ECs that may contribute to blood-brain barrier dysfunction and stroke development. Their findings suggest that the apelinergic axis, specifically the Aplnr gene and its receptor, may play a critical role in maintaining blood-brain barrier integrity and vascular health.
Pubmed:
37609982
DOI:
10.1161/JAHA.123.031044
Yeganeh-Hajahmadi M, et al. "Apelin receptor dimerization and oligomerization.." Current molecular pharmacology, 2023.
The role of Apelin and its receptor in maintaining cardiovascular and fluid homeostasis has been extensively studied. Various diseases, including diabetes, hypertension, obesity, cancer, and diabetic retinopathy, have been found to be associated with this system. As a result, there is significant interest in targeting this system for therapeutic purposes. Recent research has shown that G protein-coupled receptors (GPCRs), including the apelin receptor (APJ), have the ability to form oligomers and dimers with themselves and other receptors, altering their signaling pathways. This article explores the dimerization and oligomerization processes of APJ and its effects on signaling pathways.
Pubmed:
37594154
DOI:
10.2174/1874467217666230818113538
