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    mProX™ Human APLNR Stable Cell Line

    [CAT#: S01YF-0923-PY19]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    APLNR
    Target Family
    Apelin Family
    Target Protein Species
    Human
    Host Cell Type
    5-8F;HNE-1;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Dementia;Immune Deficienct Disease
    Gene ID
    Human: 187
    UniProt ID
    Human: P35414

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The APLNR gene, encoding the apelin receptor, has garnered attention in the scientific community for its diverse roles in physiological processes and disease progression. Recent research has shown that targeting the APLN/APLNR signaling pathway can improve antiangiogenic effects in glioblastoma while simultaneously reducing tumor cell infiltration. Another study emphasized the role of APLNR in glioma progression, where it was found to stimulate cell proliferation through the NFAT5/AKT feedback loop. Moreover, the APLNR gene has been implicated in the regulation of fatty acid oxidation energetics, with p53-mediated repression of the PGC1A and APLNR signaling pathways. Furthermore, the apelin/APLNR system has been suggested as a potential therapeutic target for essential hypertension, given its association with the risk of development in certain populations. In summary, the APLNR gene has a multifaceted role in scientific research, with implications ranging from cancer progression to metabolic regulation and cardiovascular health.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human APLNR Stable Cell Line (S01YF-0923-PY19). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Kevin (Verified Customer)

    Is APLNR only associated with cardiovascular functions? Aug 09 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    No, while APLNR plays a significant role in cardiovascular functions, it is also implicated in tumor progression and other cellular processes. Aug 09 2021

    chat Lisa (Verified Customer)

    Can targeting APLNR improve the efficiency of antiangiogenic treatments in glioblastoma? Aug 25 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Yes, targeting the APLN/APLNR pathway can enhance the efficiency and reduce the side effects of established antiangiogenic treatments for certain glioblastoma subtypes. Aug 25 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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