mProX™ Human AGTR2 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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InquiryBased on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.
| Sub Cat | Product Name | Target Protein Species | Host Cell Type | Assay Types | Inquiry | Datasheet |
|---|---|---|---|---|---|---|
| S01YF-1122-KX220 | Magic™ Dog AGTR2 in Vitro Radioligand Binding Assay | Dog | CHO-K1 | Radioligand Binding Assay |
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 Effects of AGTR2 knockdown on proliferation
Knockdown of AGTR2 increased cell proliferation with extrinsic A-II in HSC3 cells.
Ref: Matsushima-Otsuka, Sayako, et al. "Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma." Oncotarget 9.93 (2018): 36561.
Pubmed: 30564297
DOI: 10.18632/oncotarget.26337
Research Highlights
Tayler HM, et al. "Altered gene expression within the renin-angiotensin system in normal ageing and ." The journals of gerontology. Series A, Biological sciences and medical sciences, 2023.
In the present study, the authors examined gene expression of ACE1, AGTR1, AGTR2, ACE2, LNPEP, and MAS1 using the 2-,àÜ,àÜCq method in 177 individuals categorized as BS0-II (n = 48), BSIII-IV (n = 44), and BSV-VI (n = 85). The analysis was adjusted for reference genes (RPL13 and UBE2D2) and cell-specific calibrator genes (NEUN, GFAP, PECAM). They found that in normal aging, expression of ACE1 and AGTR1, markers of classical RAS signaling, and AGTR2 were elevated while markers of protective downstream regulatory RAS signaling (ACE2, MAS1, and LNPEP) remained unchanged. In patients with Alzheimer's disease (AD) and mixed dementia, expression of AGTR1 and AGTR2 were elevated in BSIII-IV and BSV-VI, respectively. MAS1 expression was lower in BSV-VI and was found to be inversely related to parenchymal Abeta and tau load. LNPEP expression was specifically higher in vascular dementia (VaD). These findings provide new insights into RAS signaling in both normal aging and dementia.
Pubmed:
37813091
DOI:
10.1093/gerona/glad241
Chung IH, et al. "Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing ." International journal of molecular sciences, 2023.
In this study, the authors analyzed the genetic factors underlying schizophrenia and affective disorders in two families through whole genome sequencing. While no de novo, autosomal dominant, or recessive pathogenic or likely pathogenic variants were detected in these families, several rare inherited variants of unknown significance were identified in the probands. Notably, four rare variants were found in genes associated with schizophrenia in family 1, and three rare variants were shared by two sisters with major depressive disorder in family 2. These findings suggest that inherited rare variants may contribute to the development of psychiatric disorders and may interact with each other to influence susceptibility.
Pubmed:
37511534
DOI:
10.3390/ijms241411777
