mProX™ Human ADRB1 Stable Cell Line

Product Information

Target Protein

ADRB1

Target Family

Adrenergic Family

Target Protein Species

Human

Host Cell Type

Adipocyte;(TERT-hBA);CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cardiovascular Research

Related Diseases

Resting Heart Rate, Variation In;Short Sleep, Familial Natural, 2

Gene ID

Human: 153

UniProt ID

Human: P08588

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ADRB1 gene, encoding the beta-1 adrenergic receptor, has been extensively studied for its role in various physiological and pathological processes. This receptor is primarily found in the heart and kidneys and plays a pivotal role in the regulation of heart rate and blood pressure. Recent research has shown that mechanical force-induced activation of Adrb2 in Periodontal Ligament Cells (PDLCs) contributes to the sympathetic nervous system-regulated orthodontic tooth movement, accelerating the process through Adrab2-enhanced bone resorption. Another intriguing study revealed that ADRB1 expression was significantly higher in brain metastases from cervical cancer, suggesting a potential role in metastatic processes. Furthermore, polymorphisms in the ADRB1 gene have been associated with obesity, arterial hypertension, and metabolic disorders. In patients with a history of myocardial infarction, the expression level of the ADRB1 gene in the myocardium has been correlated with myocardial contractile dysfunction. Moreover, the ADRB1 gene has been implicated in Takotsubo (stress) cardiomyopathy syndrome, a condition characterized by transient left ventricular dysfunction. In summary, the ADRB1 gene has a multifaceted role in scientific research, with implications in cardiovascular health, metabolic disorders, and cancer metastasis.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat William (Verified Customer)

What is the significance of ADRB1 in scientific research? Jan 16 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

ADRB1 has been studied in various contexts, including its role in oxidative stress injury induced by hydrogen peroxide in hepatocytes. Jan 16 2022

chat Carol (Verified Customer)

How does ADRB1 relate to apoptosis? Jul 11 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

ADRB1 is associated with the regulation of apoptosis-related proteins, which play a crucial role in cell survival and death. Jul 11 2020

Published Data

Fig.1 Knockdown of ADRB1 in TERT-hBA adipocytes.

ADRB1 siRNA #1 and #2 significantly knocked down ADRB1 mRNA levels. ADRB1 mRNA levels were compared to control siRNA with the value set to one.

Ref: Riis-Vestergaard, Mette Ji, et al. "Beta-1 and not beta-3 adrenergic receptors may be the primary regulator of human brown adipocyte metabolism." The Journal of Clinical Endocrinology & Metabolism 105.4 (2020): e994-e1005.

Pubmed: 31867674

DOI: 10.1210/clinem/dgz298

Research Highlights

"beta-Adrenergic Signaling through ADRB1 Promotes CD8+ T-cell Exhaustion". Cancer discovery, 2023.
The beta1-adrenergic receptor plays a crucial role as a T-cell immune checkpoint in both chronic infection and cancer. This receptor has been identified as a potential therapeutic target due to its ability to regulate T-cell function and response in these diseases. It has been extensively studied in various contexts, and emerging evidence has highlighted its significance in modulating immune responses and disease progression. Understanding the mechanisms and functional aspects of this receptor could lead to the development of novel treatments for chronic infection and cancer.
Pubmed: 37772780 DOI: 10.1158/2159-8290.CD-RW2023-154

Fayed MS, et al. "beta1-adrenergic receptor polymorphisms: a possible genetic predictor of bisoprolol ." Future science OA, 2023.
The aim of this study was to investigate the potential association between beta1-adrenergic receptor (ADRB1) polymorphisms and the response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS). A total of 77 patients were enrolled and received bisoprolol treatment for four weeks. Baseline and treatment blood pressure and heart rate measurements were recorded. The TaqMan allelic discrimination method was used for genotyping the ADRB1 Ser49Gly and Arg389Gly variants. The results showed that patients carrying the Arg389Arg genotype experienced greater reductions in systolic and diastolic blood pressure compared to those carrying the Gly389 allele. The study suggests that the Arg389Gly polymorphism may serve as a potential predictor of bisoprolol response in ACS patients.
Pubmed: 37753361 DOI: 10.2144/fsoa-2023-0113