mProX™ Human ADRB1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The ADRB1 gene, encoding the beta-1 adrenergic receptor, has been extensively studied for its role in various physiological and pathological processes. This receptor is primarily found in the heart and kidneys and plays a pivotal role in the regulation of heart rate and blood pressure. Recent research has shown that mechanical force-induced activation of Adrb2 in Periodontal Ligament Cells (PDLCs) contributes to the sympathetic nervous system-regulated orthodontic tooth movement, accelerating the process through Adrab2-enhanced bone resorption. Another intriguing study revealed that ADRB1 expression was significantly higher in brain metastases from cervical cancer, suggesting a potential role in metastatic processes. Furthermore, polymorphisms in the ADRB1 gene have been associated with obesity, arterial hypertension, and metabolic disorders. In patients with a history of myocardial infarction, the expression level of the ADRB1 gene in the myocardium has been correlated with myocardial contractile dysfunction. Moreover, the ADRB1 gene has been implicated in Takotsubo (stress) cardiomyopathy syndrome, a condition characterized by transient left ventricular dysfunction. In summary, the ADRB1 gene has a multifaceted role in scientific research, with implications in cardiovascular health, metabolic disorders, and cancer metastasis.