mProX™ Human ADRA2B Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 ADRA2B is required for l-adrenaline activity in blocking caspase-11 inflammasome.
Assessment of LDH and IL-1β secretion in LPS-primed BMDMs was conducted following LPS electroporation (1 μg, 16 hours) or E. coli (MOI, 25; 16 hours) exposure, with or without l-adrenaline (10 μM). The data, based on a sample size of three, is presented as means ± SD; *P < 0.05 compared to the control siRNA group, as determined by t-test.
Ref: Chen, Ruochan, et al. "cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis." Science advances 5.5 (2019): eaav5562.
Pubmed: 31131320
DOI: 10.1126/sciadv.aav5562
Research Highlights
Papageorgiou L, et al. "ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel ." Advances in experimental medicine and biology, 2023.
Mental disorders are often associated with various psychiatric conditions such as depression, bipolar disorder, schizophrenia, eating disorders, and suicidal thoughts. These complex illnesses are influenced by various biological factors and pathways. For instance, eating disorders require the involvement of geneticists, psychiatrists, and medical experts to manage their symptoms. Similarly, individuals with suicidal ideation are typically monitored by a multidisciplinary team of specialists. In this study, the authors conducted an analysis on two G protein-coupled receptors (GPCRs), ADRA2B and HTR1A, which have been linked to mental disorders and malnutrition. The aim of the study is to explore the conserved motifs in biogenic amine receptors and their role in signal transduction pathways, by combining evolutionary and structural analyses. Additionally, the structural features of ADRA2B and HTR1A are compared with other GPCRs associated with mental disorders.
Pubmed:
37525034
DOI:
10.1007/978-3-031-31978-5_7
Bordbar M, Saadat M. "Association between 15 insertion/deletion genetic polymorphisms and risk of ." EXCLI journal, 2023.
Schizophrenia is a psychiatric syndrome that affects an estimated 1% of the world's population and is a leading cause of disability. A case-control study was conducted to investigate the potential association between 15 insertion/deletion (Indel) polymorphisms and schizophrenia risk, utilizing pooled samples. The study included 361 individuals with schizophrenia and 360 healthy individuals. The examined Indel polymorphisms were found in the APOB, ADRA2B, PDCD6IP, LRPAP1, TLR2, DHFR, VEGF, HLA-G, TPA, DBH, UCP2, FADS2, MDM2, TP53 and SLC6A4 genes. Results revealed that the Del allele of the HLA-G 14bp Indel polymorphism increased the risk of schizophrenia (OR=1.23, 95% CI=1.01-1.52, p=0.045) and the Alu(-) allele of the TPA Alu(+)/Alu(-) polymorphism was negatively associated with schizophrenia risk (OR=0.67, 95% CI=0.54-0.82, p<0.001).
Pubmed:
37223083
DOI:
10.17179/excli2022-5734
