mProX™ Human ADCYAP1R1 Stable Cell Line

Product Information

Target Protein

ADCYAP1R1

Target Family

VIP/PACAP Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research; Digestive and Renal Research

Related Diseases

Post-Traumatic Stress Disorder; Accommodative Spasm

Gene ID

117

UniProt ID

P41586

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

According to reports, ADCYAP1R1 is crucial for a number of cellular functions, including the control of the circadian rhythm, the management of food intake, the regulation of glucose metabolism, learning and memory, neuronal ontogenesis, apoptosis, and immune system control. Diverse organs, including the adrenal medulla, pancreatic acini, uterus, myenteric plexus, and brain, express ADCYAP1R1. Additionally, it is expressed in the cerebral arteries, otic, trigeminal, and superior cervical ganglia. Recent research suggests that ADCYAP1R1 may play a role in post-traumatic stress disorder. Additionally, it is upstream of the MAP-KK signaling pathway, which is crucial in controlling the cell cycle. Additionally, the PAC1-R offers a possible new target for the development of small molecule drugs in the fields of immunology, cancer, and neuroscience. The customized ADCYAP1R1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Valentine

The ADCYAP1R1 Stable Cell Line is great for orphan receptor research. Mar 26 2023

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chat Catherine

Flow cytometry is used to verify the surface expression of the ADCYAP1R1 protein, and qPCR is used to verify the engineering results at the mRNA level. Jul 16 2023

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FAQ

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Published Data

Fig.1 Expression of PACAP receptors in mouse BM.

Expression of the three PACAP receptor genes in mouse BM and blood (adcyap1r1, vipr1, and vip2). Receptor expression in the brain sample is utilized as a positive control whereas RT-free denotes the absence of reverse transcriptase (negative control).

Ref: Xu, Zhifang, et al. "Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor." Scientific reports 6.1 (2016): 22373.

Pubmed: 26925806

DOI: 10.1038/srep22373

Research Highlights

5-10% of US adults suffer from posttraumatic stress disorder (PTSD), with women experiencing it more frequently than males. Although the exact method by which biological sex contributes to PTSD susceptibility is still unknown, one theory suggests that estrogen may play a part in a gene-by-environment interaction.
Mercer, K. B., et al. "Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1." Translational psychiatry 6.12 (2016): e978-e978.
Pubmed: 27959335 DOI: 10.1038/tp.2016.241

Adult PTSD has been linked to dysregulated fear conditioned responses, with greater fear-potentiated startle (FPS) acting as a possible intermediary phenotype for PTSD risk. In adult women, stress-related ADCYAP1R1 gene variations have also been linked to this behavior.
Jovanovic, Tanja, et al. "Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex." Neuropsychopharmacology 45.10 (2020): 1603-1608.
Pubmed: 32590837 DOI: 10.1038/s41386-020-0748-2