Human PDGFRa Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX317]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein mRNA
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order LNP-mRNA encoding human PDGFRa.
Target Protein
PDGFRa
Target Protein Species
Human
Target Classificationp
Kinases/Enzyme
Target Research Area
Cancer Research; Cardiovascular Research; Digestive and Renal Research
Related Diseases
Gist-Plus Syndrome; Hypereosinophilic Syndrome
Target Family
Kinases/Enzyme
RNA Type
LNP-mRNA
Nucleoside Modification Method
m1Ψ; m5C or specific requirements
Cap
Cap 0; Cap 1 or specific requirements
PolyA Tail (nt)
30 nt; 80 nt; 120 nt or specific requirements
5' UTR
Human globin alpha; 5' UTR seq can be modified according to the specific requirements
Promoter
T7
Tag
Based on specific requirements
Fluorescent Markers
Based on specific requirements
Formation
LNP Encapsulation mRNA
LNP Formulation
Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
Buffer
Tris buffer or PBS
Quality Control
OD260/280 (~1.90-2.50)
PASS
Agarose Gel Mobility
PASS
Sequence and Enzyme Digestion
PASS
Encapsulation Efficiency
PASS
mRNA Transfection Efficiency
PASS
Product Properties
Application
Drug discovery research and pre-clinical studies
Shipping
Blue Ice
Storage
Aliquot and store at 2-8°C for long term.
Target
Full Name
Platelet derived growth factor receptor alpha
Introduction
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Alternative Names
PDGFRA; CD140A; PDGFR2; PDGFR-2; platelet-derived growth factor receptor alpha; CD140 antigen-like family member A; CD140a antigen; PDGF-R-alpha; alpha-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 2; platelet-derived growth factor receptor, alpha polypeptide; Platelet derived growth factor receptor alpha
Gene ID
UniProt ID
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