Human KDR Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX302]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein mRNA
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order LNP-mRNA encoding human KDR.
Target Protein
KDR
Target Protein Species
Human
Target Classificationp
Kinases/Enzyme
Target Research Area
Cancer Research
Related Diseases
Hemangioma
Target Family
Kinases/Enzyme
RNA Type
LNP-mRNA
Nucleoside Modification Method
m1Ψ; m5C or specific requirements
Cap
Cap 0; Cap 1 or specific requirements
PolyA Tail (nt)
30 nt; 80 nt; 120 nt or specific requirements
5' UTR
Human globin alpha; 5' UTR seq can be modified according to the specific requirements
Promoter
T7
Tag
Based on specific requirements
Fluorescent Markers
Based on specific requirements
Formation
LNP Encapsulation mRNA
LNP Formulation
Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
Buffer
Tris buffer or PBS
Quality Control
OD260/280 (~1.90-2.50)
PASS
Agarose Gel Mobility
PASS
Sequence and Enzyme Digestion
PASS
Encapsulation Efficiency
PASS
mRNA Transfection Efficiency
PASS
Product Properties
Application
Drug discovery research and pre-clinical studies
Shipping
Blue Ice
Storage
Aliquot and store at 2-8°C for long term.
Target
Full Name
Kinase insert domain receptor
Introduction
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Alternative Names
KDR; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; Kinase insert domain receptor
Gene ID
UniProt ID
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