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  • Human FGFR2 Membrane Protein LNP Encapsulation mRNA

    [CAT#: S01YF-1124-KX282]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein mRNA

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    Certificate of Analysis Lookup
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    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order LNP-mRNA encoding human FGFR2.
    Target Protein
    FGFR2
    Target Protein Species
    Human
    Target Classificationp
    Kinases/Enzyme
    Target Research Area
    Metabolic Research
    Related Diseases
    Pfeiffer Syndrome; Crouzon Syndrome
    Target Family
    Kinases/Enzyme
    RNA Type
    LNP-mRNA
    Nucleoside Modification Method
    m1Ψ; m5C or specific requirements
    Cap
    Cap 0; Cap 1 or specific requirements
    PolyA Tail (nt)
    30 nt; 80 nt; 120 nt or specific requirements
    5' UTR
    Human globin alpha; 5' UTR seq can be modified according to the specific requirements
    Promoter
    T7
    Tag
    Based on specific requirements
    Fluorescent Markers
    Based on specific requirements
    Formation
    LNP Encapsulation mRNA
    LNP Formulation
    Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
    Buffer
    Tris buffer or PBS

    Quality Control

    OD260/280 (~1.90-2.50)
    PASS
    Agarose Gel Mobility
    PASS
    Sequence and Enzyme Digestion
    PASS
    Encapsulation Efficiency
    PASS
    mRNA Transfection Efficiency
    PASS

    Product Properties

    Application
    Drug discovery research and pre-clinical studies
    Shipping
    Blue Ice
    Storage
    Aliquot and store at 2-8°C for long term.

    Target

    Full Name
    Fibroblast growth factor receptor 2
    Introduction
    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
    Alternative Names
    FGFR2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; BEK fibroblast growth factor receptor; bacteria-expressed kinase; keratinocyte growth factor receptor; protein tyrosine kinase, receptor like 14; Fibroblast growth factor receptor 2
    Gene ID
    UniProt ID

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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