FGFR2
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
| Full Name | fibroblast growth factor receptor 2 |
| Gene ID | Human: 2263 Mouse: 14183 Rat: 25022 Monkey: 715949 |
| UniProt ID | Human: P21802 Mouse: P21803 Rat: Q9R294 |
| Alternative Names | BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM;fibroblast growth factor receptor 2;BEK fibroblast growth factor receptor;bacteria-expressed kinase;keratinocyte growth factor receptor;protein tyrosine kinase, receptor like 14 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR2 & AHCYL1 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR2 & BICC1 (K659E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR2 & BICC1 (Y375C) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: NSCLC; CHO-K1; HEK293
