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  • Human AR Membrane Protein LNP Encapsulation mRNA

    [CAT#: S01YF-1124-KX233]
    Product Category:
    Membrane Protein Tools
    Subcategory:
    Membrane Protein mRNA

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    Certificate of Analysis Lookup
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    Lot Number

    Product Information

    Product Overview
    This product is a made-to-order LNP-mRNA encoding human AR.
    Target Protein
    AR
    Target Protein Species
    Human
    Target Classificationp
    Nuclear Receptor
    Target Research Area
    Inflammation Research; Reproductive Research
    Related Diseases
    Androgen Insensitivity; Partial and Spinal And Bulbar Muscular Atrophy
    Target Family
    Nuclear Receptor
    RNA Type
    LNP-mRNA
    Nucleoside Modification Method
    m1Ψ; m5C or specific requirements
    Cap
    Cap 0; Cap 1 or specific requirements
    PolyA Tail (nt)
    30 nt; 80 nt; 120 nt or specific requirements
    5' UTR
    Human globin alpha; 5' UTR seq can be modified according to the specific requirements
    Promoter
    T7
    Tag
    Based on specific requirements
    Fluorescent Markers
    Based on specific requirements
    Formation
    LNP Encapsulation mRNA
    LNP Formulation
    Conventional and custom formulation with helper lipid, lonizable lipid, cholesterol and lipid-anchored PEG
    Buffer
    Tris buffer or PBS

    Quality Control

    OD260/280 (~1.90-2.50)
    PASS
    Agarose Gel Mobility
    PASS
    Sequence and Enzyme Digestion
    PASS
    Encapsulation Efficiency
    PASS
    mRNA Transfection Efficiency
    PASS

    Product Properties

    Application
    Drug discovery research and pre-clinical studies
    Shipping
    Blue Ice
    Storage
    Aliquot and store at 2-8°C for long term.

    Target

    Full Name
    Androgen receptor
    Introduction
    The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.
    Alternative Names
    KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4
    Gene ID
    UniProt ID

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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