mProX™ Human AR Stable Cell Line

Product Information

Target Protein

Target Family

3-Ketosteroid Receptor

Target Protein Species

Human

Host Cell Type

MDA-MB-453; HCC1428; CHO-K1; HEK293

Target Classification

Nuclear Receptor

Target Research Area

Inflammation Research; Reproductive Research

Related Diseases

Androgen Insensitivity; Partial and Spinal And Bulbar Muscular Atrophy

Gene ID

367

UniProt ID

P10275

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The AR gene codes for the production of an androgen receptor protein. Hormones known as androgens, such testosterone, are essential for a healthy male sexual development both before and during puberty. The body may react to these hormones in a proper manner thanks to androgen receptors. The receptors bind to androgens and are found in many different tissues throughout the body. Following its formation, the androgen-receptor complex attaches to DNA to control the expression of genes that respond to androgen. The androgen receptor helps control the development of male sexual traits by activating or inactivating genes as needed. In addition, androgens and androgen receptors play critical roles in controlling sex drive and hair growth in both males and females. The customized AR stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Ashley

The AR cell line design is well-optimized, and the provided documentation is comprehensive. It has saved me time and effort compared to traditional methods. Mar 03 2021

chat Verified Customer

chat Thomas

Most importantly, I would recommend this product to anyone who wants to research AR. Jul 08 2022

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Research Highlights

The AR has a wide range of biological activities, including significant involvement in the development and maintenance of the reproductive, musculoskeletal, cardiovascular, immunological, neurological, and hemopoietic systems. This is due to its ubiquitous expression in many cells and tissues.
Davey, Rachel A., and Mathis Grossmann. "Androgen receptor structure, function and biology: from bench to bedside." The clinical biochemist reviews 37.1 (2016): 3.
Pubmed: 27057074 DOI: PMC4810760

An essential part of the manifestation of the male phenotype is played by androgens and androgen receptors (AR). Changes in AR functions have been linked to a number of illnesses, including prostate cancer and androgen insensitivity syndrome (AIS).
Tan, M. H., et al. "Androgen receptor: structure, role in prostate cancer and drug discovery." Acta Pharmacologica Sinica 36.1 (2015): 3-23.
Pubmed: 24909511 DOI: 10.1038/aps.2014.18