Bombesin GPCR Assays

Background of Bombesin Receptors

The bombesin receptors are G protein-coupled receptors. They are activated when bind to endogenous ligands, including gastrin-releasing peptide (GRP), neuromedin B (NMB), and GRP18-27 (neuromedin C). The corresponding receptors are divided into three subtypes, including the NMB receptor (BB₁ receptor), GRP receptor (BB₂ receptor), and an orphan receptor (BB₃ receptor).

Fig.1. Proposed molecular mechanisms mediating GRPR regulation of brain function. (Roesler, 2012)

Distribution and Function of Bombesin Receptors

The bombesin receptors are broadly expressed throughout the central nervous system (CNS), gastrointestinal tract, and other organs, which are responsible for many physiological and pathologic processes, such as the modulation of sensory transmission, thermoregulation, feeding and pituitary, gastric, and pancreatic secretion, tissue development, as well as the regulation of lung cancer, eating disorder and obesity, CNS diseases, memory loss and behavior disorders, and inflammatory diseases.

Subtypes and Mechanisms of Bombesin Receptors

The family of bombesin receptors contains three subtypes of receptors, BB₁ receptor, BB₂ receptor, and BB₃ receptor. They all promote signal transduction through the family of G_q/G₁₁ proteins.

Assay List of Bombesin Receptors

Creative Biolabs can provide a range of assays of bombesin receptors. You can choose the assay in the list or contact us for more information:

Published Data

References

1. Roesler, R.; Schwartsmann, G. Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target. Frontiers in endocrinology. 2012, 3, 159.
2. Moody, T. W.; et al. ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides. 2015, 64: 55-61.