ZAP70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
| Full Name | zeta chain of T cell receptor associated protein kinase 70 |
| Gene ID | Human: 7535 Mouse: 22637 Rat: 301348 Monkey: 707555 |
| UniProt ID | Human: P43403 Mouse: P43404 Rat: A0A8I6AHV6 |
| Alternative Names | SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70;tyrosine-protein kinase ZAP-70;70 kDa zeta-associated protein;70 kDa zeta-chain associated protein;syk-related tyrosine kinase;zeta chain of T cell receptor associated protein kinase 70kDa;zeta-chain (TCR) associated protein kinase 70kDa;zeta-chain associated protein kinase, 70kD |
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mProX™ Human ZAP70 Stable Cell Line
[CAT#: S01YF-1023-PY138]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;697;Jurkat;Reh
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