mProX™ Human ZAP70 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

ZAP70, a protein tyrosine kinase, has various applications in different contexts. In chronic lymphocytic leukemia (CLL), ZAP70 expression in CLL cells has prognostic value and is associated with autoimmune cytopenia. ZAP70 expression is also observed in normal B cells from CLL patients, suggesting its potential role in early B-cell development and autoimmune complications. Additionally, ZAP70 is involved in T-cell development and the regulation of T-cell receptor (TCR) expression. It modulates the TCR signaling pathway, affects TCR expression on the T-cell surface, and regulates negative and positive selection of developing thymocytes. Furthermore, ZAP70 is implicated in intestinal inflammation induced by ammonia nitrogen stress in yellow catfish, where its positive signal is associated with the expression of inflammation-related genes. In the context of mature B-cell neoplasms, CD200 expression, along with other markers including ZAP70, is useful for the differential diagnosis of these disorders. Overall, ZAP70 plays a crucial role in CLL leukemogenesis, T-cell development and activation, and the pathogenesis of autoimmune complications and intestinal inflammation.