TNFSF8
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
| Full Name | TNF superfamily member 8 |
| Gene ID | Human: 944 Mouse: 21949 Rat: 683163 Monkey: 702944 |
| UniProt ID | Human: P32971 Mouse: P32972 Rat: M0R3V3 Monkey: F7BXW3 |
| Alternative Names | TNFSF8; CD153; CD30L; CD30LG; TNLG3A; tumor necrosis factor ligand superfamily member 8; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; tumor necrosis factor (ligand) superfamily, member 8; tumor necrosis factor ligand 3A; tumor necrosis factor superfamily member 8; TNF superfamily member 8 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TNFSF8 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Oncology Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;PC12 Assay Types: Biological assays
