mProX™ Human TNFSF8 Stable Cell Line

Product Information

Target Family

Oncology

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;PC12

Target Classification

Oncology Cell Lines

Target Research Area

Cancer Research;Immunology Research

Related Diseases

Anaplastic Large Cell Lymphoma; Lymphoma, Hodgkin, Classic

Gene ID

Human:944

UniProt ID

Human:P32971

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TNFSF8, also known as CD30 ligand, is a gene that has been studied in various medical contexts. In pediatric Chronic Active Epstein-Barr Virus Infection, TNFSF8 is identified as one of the key genes associated with the disease. It is found to be up-regulated in pediatric CAEBV compared to pediatric acute infectious mononucleosis (AIM), and its expression is correlated with myeloid cell enrichment and persistent EBV infection pathway. In IgA nephropathy, TNFSF8 is identified as one of the risk loci associated with the disease. It is involved in pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy. In adult T-cell leukemia/lymphoma (ATL), CD30 expression and its functions are explored during the disease progression. CD30, which is encoded by TNFSF8, plays roles in pro-survival signal induction and cell proliferation in ATL. In a Chinese Han population, TNFSF8 is found to be strongly associated with systemic sclerosis (SSc). The TNFSF8 rs1555457 T allele is significantly associated with SSc, and patients carrying the TNFSF8 rs1555457 TT genotype have an increased risk of SSc. These studies highlight the diverse applications of TNFSF8 in different diseases and provide insights into its role in disease development and progression.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Taylor Davis (Verified Customer)

What role does TNFSF8 play in pancreatic cancer? Mar 27 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TNFSF8 has been found to promote metastasis in pancreatic cancer, potentially through pathways like Wnt/Snail signaling and M2 polarization of macrophages. Mar 27 2021

chat Cameron Smith (Verified Customer)

How does TNFSF8 affect immune responses? Nov 15 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

TNFSF8 is involved in modulating T-cell proliferation and plays a role in immune responses, as seen in its association with diseases like Behçet's disease and Takayasu arteritis. Nov 15 2021

Published Data

Fig.1 The assessment of potential target genes associated with apoptosis and mitochondrial biogenesis in PC12 cells was conducted through western blotting analysis, revealing outcomes influenced by the experimental procedure.

The protein expression of ATN1, USP25, and TNFSF8 was silenced using short interfering RNAs (siRNAs), and the effects of protein expression silencing on apoptosis and mitochondrial biogenesis after OGD/R were examined via western blot analysis. A significant reduction in the protein levels of cleaved caspase 3 and Bax, along with the promotion of the expression of mitochondrial biogenesis-related proteins, such as PGC-1α, NRF1, and TFAM, was observed upon the inhibition of TNFSF8.

Ref: Zhang, Qiang, et al. "Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway." Cellular and Molecular Neurobiology 43.5 (2023): 2179-2202.

Pubmed: 36266523

DOI: 10.1007/s10571-022-01296-3

Research Highlights

Zhang, Yi. et al. "Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus Infection." Cellular and molecular biology (Noisy-le-Grand, France), 2023.
Chronic active Epstein-Barr virus infection (CAEBV) is a serious condition with a poor prognosis and high mortality rate. A research team conducted a bioinformatics analysis to identify key genes associated with CAEBV. They used weighted gene co-expression network analysis (WGCNA) to identify a gene module highly correlated with pediatric CAEBV and investigated the differentially expressed genes (DEGs) between pediatric acute infectious mononucleosis (AIM) and pediatric CAEBV. By using the least absolute shrinkage and selection operator (LASSO) and random forest algorithms, they identified three key genes (TPST1, TNFSF8, and RAB3GAP1) associated with pediatric CAEBV. These genes have a strong diagnostic performance in distinguishing between pediatric CAEBV and AIM. Further analysis showed that these genes are related to inflammatory response and inflammation-related pathways, as well as myeloid cell enrichment and persistent Epstein-Barr virus infection pathway. This study provides new insights into the development of CAEBV and highlights the potential of TPST1, TNFSF8, and RAB3GAP1 as therapeutic targets for this condition.
Zhang, Yi. et al. "Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus Infection." Cellular and molecular biology (Noisy-le-Grand, France), 2023.
Pubmed: 37715397 DOI: 10.14715/cmb/2023.69.7.27

Kiryluk, Krzysztof. et al. "Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy." Nature genetics, 2023.
IgAN is a progressive kidney disease characterized by the presence of IgA in glomeruli. A genome-wide association study was conducted on 10,146 biopsy-diagnosed IgAN patients and 28,751 controls from 17 international cohorts. Thirty genome-wide significant risk loci were identified, with 16 being new, including TNFSF4/TNFSF18, REL, CD28, PF4V1, LY86, LYN, ANXA3, TNFSF8/TNFSF15, REEP3, ZMIZ1, OVOL1/RELA, ETS1, IGH, IRF8, TNFRSF13B, and FCAR. These loci showed an enrichment of genes that cause abnormal IgA levels in mice. Additionally, a genetic correlation was observed between IgAN and serum IgA levels, and a high polygenic score for IgAN was associated with an earlier onset of kidney failure. Functional analysis of candidate causal genes revealed a convergence of inflammatory signaling pathways and cytokine ligand-receptor pairs, highlighting potential new drug targets. This study provides valuable insights into the genetic basis of IgAN and may aid in the development of targeted treatments for this disease.
Kiryluk, Krzysztof. et al. "Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy." Nature genetics, 2023.
Pubmed: 37337107 DOI: 10.1038/s41588-023-01422-x