mProX™ Human TNFSF8 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TNFSF8, also known as CD30 ligand, is a gene that has been studied in various medical contexts. In pediatric Chronic Active Epstein-Barr Virus Infection, TNFSF8 is identified as one of the key genes associated with the disease. It is found to be up-regulated in pediatric CAEBV compared to pediatric acute infectious mononucleosis (AIM), and its expression is correlated with myeloid cell enrichment and persistent EBV infection pathway. In IgA nephropathy, TNFSF8 is identified as one of the risk loci associated with the disease. It is involved in pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy. In adult T-cell leukemia/lymphoma (ATL), CD30 expression and its functions are explored during the disease progression. CD30, which is encoded by TNFSF8, plays roles in pro-survival signal induction and cell proliferation in ATL. In a Chinese Han population, TNFSF8 is found to be strongly associated with systemic sclerosis (SSc). The TNFSF8 rs1555457 T allele is significantly associated with SSc, and patients carrying the TNFSF8 rs1555457 TT genotype have an increased risk of SSc. These studies highlight the diverse applications of TNFSF8 in different diseases and provide insights into its role in disease development and progression.