TNFRSF1B
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
| Full Name | TNF receptor superfamily member 1B |
| Gene ID | Human: 7133 Mouse: 21938 Rat: 156767 Monkey: 715454 |
| UniProt ID | Human: P20333 Mouse: P25119 Rat: Q80WY6 Monkey: F7EAF8 |
| Alternative Names | TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II; TNF receptor superfamily member 1B |
Product List
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mProX™ Human TNFRSF1B Stable Cell Line
[CAT#: S01YF-1023-PY260]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;HT29;NCM460
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