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    mProX™ Human TNFRSF1B Stable Cell Line

    [CAT#: S01YF-1023-PY260]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HT29;NCM460
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Cancer Research
    Related Diseases
    Classic Mycosis Fungoides; Sezary's Disease
    Gene ID
    Human:7133
    UniProt ID
    Human:P20333

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    TNFRSF1B, also known as tumor necrosis factor receptor superfamily member 1B, has been studied in various contexts. In idiopathic pulmonary hypertension (IPAH), TNFRSF1B is identified as one of the biomarkers that can aid in the diagnosis of the disease. In colitis, TNFRSF1B is upregulated and plays a role in terminating epithelial regenerative signaling to restore homeostasis. In hepatocellular carcinoma (HCC), TNFRSF1B is involved in resistance to Lenvatinib plus anti-PD1 antibodies treatment through the TNF-TNFRSF1B pathway. In ovarian cancer, TNFRSF1B is identified as a novel T-cell exhaustion marker and a potential immunotherapy target. In lung cancer, both TNFR1 and TNFR2, encoded by TNFRSF1A and TNFRSF1B respectively, are implicated in lung cancer progression, cell dedifferentiation, and metastasis. These findings highlight the diverse applications of TNFRSF1B in different diseases and provide insights into potential therapeutic targets.

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    FAQ

    chat Jordan Smith (Verified Customer)

    What role does TNFRSF1B play in intestinal inflammation? Sep 04 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TNFRSF1B is regulated by long non-coding RNA NEAT1, which promotes NF-κB p65 translocation and mediates intestinal inflammation, indicating its potential as a therapeutic target in inflammatory bowel diseases. Sep 04 2020

    chat Skyler Brown (Verified Customer)

    Can TNFRSF1B serve as a biomarker for ovarian cancer? Oct 04 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    TNFRSF1B has been identified as a novel T-cell exhaustion marker in ovarian cancer, suggesting its potential as an immunotherapy target and its role in the tumor microenvironment. Oct 04 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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