mProX™ Human TNFRSF1B Stable Cell Line

Product Information

Target Family

Other Targets

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HT29;NCM460

Target Classification

Other Targets Drug Discovery Assays and Products

Target Research Area

Cancer Research

Related Diseases

Classic Mycosis Fungoides; Sezary's Disease

Gene ID

Human:7133

UniProt ID

Human:P20333

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

TNFRSF1B, also known as tumor necrosis factor receptor superfamily member 1B, has been studied in various contexts. In idiopathic pulmonary hypertension (IPAH), TNFRSF1B is identified as one of the biomarkers that can aid in the diagnosis of the disease. In colitis, TNFRSF1B is upregulated and plays a role in terminating epithelial regenerative signaling to restore homeostasis. In hepatocellular carcinoma (HCC), TNFRSF1B is involved in resistance to Lenvatinib plus anti-PD1 antibodies treatment through the TNF-TNFRSF1B pathway. In ovarian cancer, TNFRSF1B is identified as a novel T-cell exhaustion marker and a potential immunotherapy target. In lung cancer, both TNFR1 and TNFR2, encoded by TNFRSF1A and TNFRSF1B respectively, are implicated in lung cancer progression, cell dedifferentiation, and metastasis. These findings highlight the diverse applications of TNFRSF1B in different diseases and provide insights into potential therapeutic targets.

Protocols

Please visit our protocols page.

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FAQ

chat Jordan Smith (Verified Customer)

What role does TNFRSF1B play in intestinal inflammation? Sep 04 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

TNFRSF1B is regulated by long non-coding RNA NEAT1, which promotes NF-κB p65 translocation and mediates intestinal inflammation, indicating its potential as a therapeutic target in inflammatory bowel diseases. Sep 04 2020

chat Skyler Brown (Verified Customer)

Can TNFRSF1B serve as a biomarker for ovarian cancer? Oct 04 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

TNFRSF1B has been identified as a novel T-cell exhaustion marker in ovarian cancer, suggesting its potential as an immunotherapy target and its role in the tumor microenvironment. Oct 04 2022

Published Data

Fig.1 The increase in inflammation level was counteracted by the overexpression of TNFRSF1B following NEAT1 knockdown.

The protein expression levels of TNFRSF1B, NF-κB p65, and p-NF-κB p65, as well as proliferation and inflammation-related factors IL1R1 and Caspase-4, were measured in various groups. NEAT1, denoted as nuclear enriched abundant transcript 1; IL1R1, referred to as interleukin 1 receptor type I; TNFRSF1B, known as tumor necrosis factor superfamily member 1B; TNF-α, recognized as tumor necrosis factor-alpha; and NF-κB, referred to as nuclear factor-kappa B, were assessed in the study.

Ref: Pan, Shiyu, et al. "LncRNA NEAT1 mediates intestinal inflammation by regulating TNFRSF1B." Annals of Translational Medicine 9.9 (2021).

Pubmed: 34268386

DOI: 10.21037/atm-21-34

Research Highlights

Lu, Wenzhang. et al. "Identication and validation of cell senescence biomarkers in idiopathic pulmonary hypertension via integrated transcriptome analyses and machine learning." Experimental gerontology, 2023.
Idiopathic pulmonary hypertension (IPAH) is a rare and severe disease that impacts the pulmonary vasculature and is difficult to diagnose. Due to the invasive nature of the diagnostic procedure, early detection of IPAH is a challenge. Therefore, examining biomarkers found in peripheral blood may assist in the timely identification and treatment of IPAH. This research is crucial in improving the management and prognosis of patients with IPAH.
Lu, Wenzhang. et al. "Identication and validation of cell senescence biomarkers in idiopathic pulmonary hypertension via integrated transcriptome analyses and machine learning." Experimental gerontology, 2023.
Pubmed: 37776984 DOI: 10.1016/j.exger.2023.112303

Sharifkhodaei, Zohreh. et al. "Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis." iScience, 2023.
The repair process of colonic epithelium is essential for overall health. This process includes alterations in epithelial differentiation, a significant increase in cell proliferation, and activation of regeneration-associated genes such as murine_mt-1 and MRL. These genes are typically expressed during early stages of development and may play a crucial role in the repair of damaged colonic tissue. Understanding the mechanisms involved in these repair processes could provide valuable insights into maintaining colonic health and preventing diseases.
Sharifkhodaei, Zohreh. et al. "Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis." iScience, 2023.
Pubmed: 37736049 DOI: 10.1016/j.isci.2023.107829