TLR4
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.
| Full Name | Toll like receptor 4 |
| Gene ID | Human: 7099 Mouse: 21898 Rat: 29260 Monkey: 574360 |
| UniProt ID | Human: O00206 Mouse: Q9QUK6 Rat: Q9QX05 Monkey: F7E9T3 |
| Alternative Names | TLR4; TOLL; CD284; TLR-4; ARMD10; hToll; homolog of Drosophila toll; toll like receptor 4 protein; toll-like receptor 4; Toll like receptor 4 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR4 & CD14 & MD2 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR4 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR4 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR4 & CD14 & MD2 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR4 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR4 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;HAECs
