TLR3
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
| Full Name | Toll like receptor 3 |
| Gene ID | Human: 7098 Mouse: 142980 Rat: 364594 Monkey: 574378 |
| UniProt ID | Human: O15455 Mouse: Q99MB1 Rat: Q7TNI8 Monkey: F7DWP4 |
| Alternative Names | TLR3; CD283; IIAE2; Toll like receptor 3 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR3 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR3 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR3 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TLR3 Target Family: Immune Checkpoint Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1
