TGFBR2

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Full Name	transforming growth factor beta receptor 2
Gene ID	Human: 7048 Mouse: 21813 Rat: 81810 Monkey: 703088
UniProt ID	Human: P37173 Mouse: Q62312 Rat: P38438
Alternative Names	AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; tbetaR-II; TGFbeta-RII;TGF-beta receptor type-2;TGF-beta receptor type IIB;TGF-beta type II receptor;transforming growth factor beta receptor II;transforming growth factor beta receptor type IIC;transforming growth factor, beta receptor II (70/80kDa);transforming growth factor, beta receptor II alpha;transforming growth factor, beta receptor II beta;transforming growth factor, beta receptor II delta;transforming growth factor, beta receptor II epsilon;transforming growth factor, beta receptor II gamma

Product List

mProX™ Human TGFBR2 Stable Cell Line [CAT#: S01YF-1023-PY113]

Product Category:: Membrane Protein Stable Cell Lines

Datasheet

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