STAT2
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44.
| Full Name | Signal transducer and activator of transcription 2 |
| Gene ID | Human: 6773 Mouse: 20847 Rat: 288774 Monkey: 712694 |
| UniProt ID | Human: P52630 Mouse: Q9WVL2 Rat: Q5XI26 Monkey: F6R1P6 |
| Alternative Names | P113; IMD44; ISGF-3; PTORCH3; STAT113; signal transducer and activator of transcription 2; interferon alpha induced transcriptional activator; signal transducer and activator of transcription 2, 113kDa |
Product List
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Magic™ Human STAT2 & IRF9 HEK293 Cell Line with SEAP Reporter
[CAT#: S01YF-0123-KX411]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: STAT2 & IRF9 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
mProX™ Human STAT2 Stable Cell Line
[CAT#: S01YF-1023-PY216]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;A375 Assay Types: Biological assays
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