mProX™ Human STAT2 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

STAT2, a component of the JAK-STAT signaling pathway, has various applications in different fields. In the context of type 1 diabetes, STAT2 is involved in driving the hyperexpression of human leukocyte antigen class I (HLA-I) molecules on pancreatic beta-cells, which is a hallmark feature of the disease. Understanding the factors that drive HLA-I hyperexpression and the role of STAT2 in this process can provide insights into disease progression and potential therapeutic targets. Additionally, STAT2 is implicated in the inflammatory response in the gastrointestinal tract, particularly in inflammatory bowel disease (IBD). By studying the colon transcriptome of mouse strains, researchers identified modules enriched for IBD-dysregulated genes that are responsive to STAT2. This highlights the role of STAT2 in the gene-by-environment interactions underlying inflammation and IBD. In the field of virology, STAT2 is targeted by viral proteins to antagonize the type I interferon response, which is a crucial defense mechanism against viral infections. For example, Seneca Valley virus (SVV) inhibits the IFN signaling pathway by degrading STAT1, STAT2, and interferon regulatory factor 9 (IRF9) through its proteinase activity. This allows SVV to evade the host immune response and promote viral replication. Overall, STAT2 plays a significant role in autoimmune diseases, inflammatory disorders, and viral infections, making it a valuable target for research and potential therapeutic interventions.