STAT1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C.
| Full Name | Signal transducer and activator of transcription 1 |
| Gene ID | Human: 6772 Mouse: 20846 Rat: 20846 Monkey: 693650 |
| UniProt ID | Human: P42224 Mouse: P42225 Rat: F1M9D6 Monkey: F6WE02 |
| Alternative Names | CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; transcription factor ISGF-3 components p91/p84 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: STAT1 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: STAT1 Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;786-O
