SLC10A1
This gene encodes a protein that is a member of the family of integral membrane glycoproteins called sodium/bile acid cotransporters. These proteins are involved in the enterohepatic transport of bile acids. The ileal sodium/bile acid cotransporter, which has an apical cell localization and absorbs bile acids from the intestinal lumen, bile duct, and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, which is found in the basolateral membranes of hepatocytes, are two homologous transporters that are involved in the reabsorption of bile acids. This protein is crucial for maintaining the homeostasis of cholesterol since bile acids are the catabolic byproduct of cholesterol metabolism.
| Full Name | Solute carrier family 10 member 1 |
| Gene ID | Human: 6554 Mouse: 20493 Rat: 24777 Monkey: 712925 |
| UniProt ID | Human: Q14973 Mouse: O08705 Rat: P26435 Monkey: F6YRK3 |
| Alternative Names | SLC10A1; NTCP; FHCA2; sodium/bile acid cotransporter; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Na/taurocholate cotransporting polypeptide; cell growth-inhibiting gene 29 protein; growth-inhibiting protein 29; sodium/taurocholate cotransporter; sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1; solute carrier family 10 (sodium/bile acid cotransporter), member 1; Solute carrier family 10 member 1 |
Product List
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Magic™ Human SLC10A1 Drug screening assay
[CAT#: S01YF-0922-KX1569]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: SLC10A1 Target Family: SLC Transporter Target Protein Species: Human Host Cell Type: Caco-2, MDCK, HEK293, CHO, membrane vesicles, and various transfected cells lines Assay Types: Activity Assay (High throughput screening assays; Large scale single dose, duplicate profiling; IC50 profiling; Ki determination assay; Substrate determination assay )
mProX™ Human SLC10A1 Stable Cell Line
[CAT#: S01YF-1123-KX130]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: SLC10A1 Target Family: SLC Transporter Target Protein Species: Human Host Cell Type: HepG2; CHO-K1; HEK293
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