ROCK1
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
| Full Name | Rho associated coiled-coil containing protein kinase 1 |
| Gene ID | Human: 6093 Mouse: 19877 Rat: 81762 Monkey: 698223 |
| UniProt ID | Human: Q13464 Mouse: P70335 Rat: Q63644 |
| Alternative Names | ROCK-I; P160ROCK;rho-associated protein kinase 1;p160 ROCK-1;renal carcinoma antigen NY-REN-35 |
Product List
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Magic™ Human ROCK1 Assay
[CAT#: S01YF-1222-KX476]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: ROCK1 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
mProX™ Human ROCK1 Stable Cell Line
[CAT#: S01YF-1023-PY87]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;KHOS;U2OS Assay Types: Biological assays
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