ROCK1
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
| Full Name | Rho associated coiled-coil containing protein kinase 1 |
| Gene ID | Human: 6093 Mouse: 19877 Rat: 81762 Monkey: 698223 |
| UniProt ID | Human: Q13464 Mouse: P70335 Rat: Q63644 |
| Alternative Names | ROCK-I; P160ROCK;rho-associated protein kinase 1;p160 ROCK-1;renal carcinoma antigen NY-REN-35 |
Product List
Loading...
mProX™ Human ROCK1 Stable Cell Line
[CAT#: S01YF-1023-PY87]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;KHOS;U2OS
Can't find the products you're looking for? Optimize our parameters for better results.
Filter By Tag
Note: All of our products are for Research Use Only (RUO). NOT intended for diagnostic, therapeutic or clinical use. We DO NOT offer patients any direct products or services. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
