mProX™ Human ROCK1 Stable Cell Line

[CAT#: S01YF-1023-PY87]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX476	Magic™ Human ROCK1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;KHOS;U2OS

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research;Immunology Research

Related Diseases

Breast Cancer; Lung Cancer

Gene ID

Human:6093

UniProt ID

Human:Q13464

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

ROCK1 (Rho-associated coiled-coil-containing protein kinase 1) has various applications in different fields. In the context of neuropathic pain, miR-488-3p, which regulates ROCK1, has been found to alleviate pain and modulate inflammatory responses. In sheep, ROCK1 is one of the candidate genes associated with resistance to gastrointestinal nematodes. In salivary adenoid cystic carcinoma, silencing GGTase-I, which affects ROCK1, inhibits tumor migration, invasion, and proliferation. In ischemic cardiomyopathy and dilated cardiomyopathy, ROCK1 is involved in cytoskeleton regulation, mitophagy, and signal transduction activation. Additionally, a selective ROCK inhibitor has been shown to enhance blood flow recovery after hindlimb ischemia. These studies highlight the diverse roles of ROCK1 in pain, resistance to parasites, cancer progression, heart failure, and angiogenesis.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Jordan Johnson (Verified Customer)

What is the significance of ROCK1 in cancer? Sep 17 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

ROCK1 is involved in various oncogenic processes, including mechano-signaling in malignancies driven by TEAD/YAP activation and influencing metastasis in colorectal cancer. Sep 17 2020

chat Jordan Williams (Verified Customer)

How does ROCK1 affect wound healing in diabetic ulcers? Jan 20 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

Inhibition of miR-199a-5p, which targets ROCK1, promotes wound healing in diabetic rats, suggesting a role for ROCK1 in this process. Jan 20 2022

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