RET
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
| Full Name | ret proto-oncogene |
| Gene ID | Human: 5979 Mouse: 19713 Rat: 24716 Monkey: 703466 |
| UniProt ID | Human: P07949 Mouse: P35546 Rat: G3V9H8 |
| Alternative Names | PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1;proto-oncogene tyrosine-protein kinase receptor Ret;RET receptor tyrosine kinase;cadherin family member 12;cadherin-related family member 16;proto-oncogene c-Ret;rearranged during transfection;ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) |
Product List
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Human RET Membrane Protein Bacterial Expression Plasmid
[CAT#: S01YF-1124-KX779]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pBE Vector Type: Bacterial Expression Vector
Human RET Membrane Protein In Vitro Transcription (IVT) mRNA
[CAT#: S01YF-1124-KX204]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
Human RET Membrane Protein In Vitro Transcription (IVT) Plasmid
[CAT#: S01YF-1124-KX1124]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
Human RET Membrane Protein Insect Expression Plasmid
[CAT#: S01YF-1124-KX549]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pIE Vector Type: Insect Expression Vector
Human RET Membrane Protein Lentiviral Expression Plasmid
[CAT#: S01YF-1124-KX894]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pLV Vector Type: Lentiviral Expression Vector
Human RET Membrane Protein Lentivirus
[CAT#: S01YF-1124-KX89]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme
Human RET Membrane Protein LNP Encapsulation mRNA
[CAT#: S01YF-1124-KX319]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
Human RET Membrane Protein Mammalian Transient Expression Plasmid
[CAT#: S01YF-1124-KX434]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pME Vector Type: Mammalian Transient Expression Vector
Human RET Membrane Protein Retroviral Expression Plasmid
[CAT#: S01YF-1124-KX1009]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pRV Vector Type: Retroviral Expression Vector
Human RET Membrane Protein Yeast Expression Plasmid
[CAT#: S01YF-1124-KX664]
- Product Category:
- Membrane Protein Tools
- Target Protein: RET Target Family: Kinases/Enzyme Vector: pYE Vector Type: Yeast Expression Vector
Magic™ Human CCDC6 & RET (V804L) BaF3 Cell Line
[CAT#: S01YF-0324-KX179]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCDC6 & RET (V804L) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human CCDC6 & RET (V804M) BaF3 Cell Line
[CAT#: S01YF-0324-KX180]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CCDC6 & RET (V804M) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
Magic™ Human NCOA4 & RET BaF3 Cell Line
[CAT#: S01YF-0324-KX207]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: NCOA4 & RET Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
mProX™ Human RET Stable Cell Line
[CAT#: S01YF-1023-PY85]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;LNCap
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