Human RET Membrane Protein Insect Expression Plasmid
[CAT#: S01YF-1124-KX549]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein Plasmid Products
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order plasmid encoding human RET for Protein Expression.
Target Protein
RET
Target Protein Species
Human
Target Classification
Kinases/Enzyme
Target Research Area
Cancer Research; Metabolic Research
Related Diseases
Hirschsprung Disease; Thyroid Carcinoma
Target Family
Kinases/Enzyme
Vector
pIE
Vector Type
Insect Expression Vector
Note
Resistance
AmpR
Growth Temperature
37°C
Relevant Promoters
Polyhedrin
Mutation
Based on specific requirements
Expressed Tags
Based on specific requirements (Flag, StrepII, His, etc.)
Product Properties
Applications
Protein Expression
Shipping
Blue Ice
Storage
Aliquot and store at -20°C for long term.
Target
Full Name
Ret proto-oncogene
Introduction
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Alternative Names
RET; PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1; proto-oncogene tyrosine-protein kinase receptor Ret; RET receptor tyrosine kinase; cadherin family member 12; cadherin-related family member 16; proto-oncogene c-Ret; rearranged during transfection; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); Ret proto-oncogene
Gene ID
UniProt ID
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