RAF1
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
| Full Name | Raf-1 proto-oncogene, serine/threonine kinase |
| Gene ID | Human: 5894 Mouse: 110157 Rat: 24703 Monkey: 694725 |
| UniProt ID | Human: P04049 Mouse: Q99N57 Rat: P11345 |
| Alternative Names | NS5; CRAF; Raf-1; c-Raf; CMD1NN;RAF proto-oncogene serine/threonine-protein kinase;C-Raf proto-oncogene, serine/threonine kinase;Oncogene RAF1;proto-oncogene c-RAF;raf proto-oncogene serine/threonine protein kinase;v-raf-1 murine leukemia viral oncogene homolog 1;v-raf-1 murine leukemia viral oncogene-like protein 1 |
Product List
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Magic™ Human RAF1 U2OS Cell Line with pLuc Reporter, LinkLight Assay
[CAT#: S01YF-0323-KX165]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: RAF1 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
Magic™ Human RAF1 U2OS Cell Line with Reporter, LinkLight Assay
[CAT#: S01YF-0323-KX166]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: RAF1 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: 14-3-3 assay
mProX™ Human RAF1 Stable Cell Line
[CAT#: S01YF-1023-PY84]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Human colonosphere cultures
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