mProX™ Human RAF1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

RAF1 is a gene that has been found to play a role in various diseases and biological processes. In the context of melanocytic neoplasms, RAF1 fusions have been detected in Spitz tumors, including conventional melanoma, congenital nevus, and BAP-1 inactivated tumors. This suggests that RAF1 fused melanocytic neoplasms may represent a novel subgroup of Spitz tumors. In the field of plant biology, RAF1 is involved in the assembly of hexadecameric Rubisco, the most abundant enzyme on Earth. Reconstitution experiments have shown that RAF1, along with other assembly factors, is necessary for the correct folding and assembly of Rubisco. In the context of viral infections, SARS-CoV-2 has been found to suppress TLR4-induced immunity by dendritic cells through the C-type lectin receptor DC-SIGN, and blocking the kinase RAF-1 can restore immune responses. Finally, in gastric cancer, the ASH1L-AS1-ASH1L axis has been found to control NME1-mediated activation of the RAS signaling pathway, suggesting that targeting this axis may be a potential therapeutic approach for gastric cancer. Overall, RAF1 has diverse applications in different fields of research, including cancer biology, plant biology, viral infections, and therapeutic targeting.