PYCARD
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
| Full Name | PYD and CARD domain containing |
| Gene ID | Human: 29108 Mouse: 66824 Rat: 282817 Monkey: 713563 |
| UniProt ID | Human: Q9ULZ3 Mouse: Q9EPB4 Rat: G3V8L1 Monkey: F7EZX3 |
| Alternative Names | ASC; TMS; TMS1; CARD5; TMS-1; apoptosis-associated speck-like protein containing a CARD; caspase recruitment domain-containing protein 5; target of methylation-induced silencing 1 |
Product List
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Magic™ Mouse PYCARD RAW 264.7 Cell Line
[CAT#: S01YF-0123-KX450]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PYCARD Target Family: Others Target Protein Species: Mouse Host Cell Type: RAW 264.7 Assay Types: Drug screening and biological assays
Magic™ Mouse PYCARD RAW 264.7 KO-CASP11 Cell Line
[CAT#: S01YF-0123-KX452]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PYCARD Target Family: Others Target Protein Species: Mouse Host Cell Type: RAW 264.7 KO-CASP11 Assay Types: Drug screening and biological assays
Magic™ Mouse PYCARD RAW 264.7 KO-GSDMD Cell Line
[CAT#: S01YF-0123-KX451]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PYCARD Target Family: Others Target Protein Species: Mouse Host Cell Type: RAW 264.7 KO-GSDMD Assay Types: Drug screening and biological assays
Magic™ Mouse PYCARD RAW 264.7 KO-NLRC4 Cell Line
[CAT#: S01YF-0123-KX453]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PYCARD Target Family: Others Target Protein Species: Mouse Host Cell Type: RAW 264.7 KO-NLRC4 Assay Types: Drug screening and biological assays
mProX™ Human PYCARD Stable Cell Line
[CAT#: S01YF-1023-PY300]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;786-O
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