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    mProX™ Human PYCARD Stable Cell Line

    [CAT#: S01YF-1023-PY300]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;786-O
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Metabolic Research
    Related Diseases
    Muckle-Wells Syndrome; Cinca Syndrome
    Gene ID
    Human:29108
    UniProt ID
    Human:Q9ULZ3

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    PYCARD, also known as ASC (apoptosis-associated speck-like protein containing a CARD), is involved in various biological processes and diseases. In psoriasis, PYCARD is associated with PANoptosis, a form of cell death involving pyroptosis, apoptosis, and necroptosis. It plays a role in proinflammatory and immunoregulatory pathways and is a potential biomarker for psoriasis. In osteoarthritis, PYCARD is part of a pyroptosis-related signature that can be used for diagnosis and prognosis. It is also involved in choriodecidual infection and inflammation in preterm birth, as well as in breast cancer, where it is associated with pro-tumorigenic inflammation. Additionally, PYCARD activation is observed in the liver after exposure to bisphenol F, a BPA analogue. These findings highlight the diverse applications of PYCARD in understanding disease mechanisms and developing therapeutic strategies.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human PYCARD Stable Cell Line (S01YF-1023-PY300). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Taylor Brown (Verified Customer)

    What is the role of PYCARD in the immune microenvironment? Aug 14 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PYCARD, also known as ASC, plays a significant role in regulating the immune microenvironment, particularly in diseases involving chronic inflammation such as tumors and autoimmune disorders. Aug 14 2023

    chat Cameron Miller (Verified Customer)

    How does PYCARD expression correlate with prognosis in cancer? Jun 27 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    High expression of PYCARD is associated with poor prognosis and resistance to chemotherapy in cancers like glioma, indicating its potential as a prognostic biomarker. Jun 27 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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