mProX™ Human PYCARD Stable Cell Line
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- Membrane Protein Stable Cell Lines
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Patrick Liam (Creative Biolabs Scientific Support)
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Patrick Liam (Creative Biolabs Scientific Support)
Published Data
Fig.1 The impact of KIRC cell migration was examined through the reduction of PYCARD expression.
The evaluation of 786-O cell migration was carried out through the transwell migration assay to assess the impact of transfection with si-PYCARD or si-negative control (nc-PYCARD).
Ref: Zhang, Minhao, et al. "Immune-pyroptosis-related genes predict the prognosis of kidney renal clear cell carcinoma." Translational Oncology 34 (2023): 101693.
Pubmed: 37315507
DOI: 10.1016/j.tranon.2023.101693
Research Highlights
Lu, Lingling. et al. "Identification of PANoptosis-related biomarkers and immune infiltration characteristics in psoriasis." Medicine, 2023.
PANoptosis has been identified as a potential key factor in the pathogenesis of psoriasis. A study was conducted to explore the correlation between PANoptosis and psoriasis. The results indicate that PANoptosis may have a significant impact on the development and progression of psoriasis, potentially influencing the effectiveness of treatment approaches. The findings of this investigation shed light on the potential role of PANoptosis in the pathophysiology of psoriasis and may contribute to the development of novel therapeutic strategies.
Lu, Lingling. et al. "Identification of PANoptosis-related biomarkers and immune infiltration characteristics in psoriasis." Medicine, 2023.
Pubmed:
37861483
DOI:
10.1097/MD.0000000000035627
Chen, Yanzhong. et al. "Integrated single-cell and bulk RNA sequencing analysis identified pyroptosis-related signature for diagnosis and prognosis in osteoarthritis." Scientific reports, 2023.
In this study, the researchers investigated the potential role of pyroptosis-related genes in osteoarthritis (OA), a common joint degenerative disease with a high disability rate. Through analysis of single-cell RNA sequencing and RNA-seq datasets related to OA, the study identified pyroptosis-related differentially expressed genes (PRDEGs) and differentially expressed genes (DEGs). Using Cox regression analysis, the study also identified three prognostic factors for OA: CASP6, NOD1, and PYCARD. Additionally, the researchers used weighted gene correlation network analysis and protein-protein interaction networks to identify 15 hub genes involved in pyroptosis-related pathways, which may serve as potential biomarkers for diagnosis and prognosis of OA. The study also explored the differences in gene expression among various chondrocyte cell clusters in OA and normal samples. This comparison led to the identification of 19 single-cell subpopulation marker genes that were significantly different in seven chondrocyte cell clusters. Further analysis showed that four of these marker genes (AGT, CTSD, CYBC, and THYS1) were associated with cartilage development and metabolism. These findings provide important insights into the molecular mechanisms underlying OA and may help in the development of future therapeutic strategies for this disabling disease.
Chen, Yanzhong. et al. "Integrated single-cell and bulk RNA sequencing analysis identified pyroptosis-related signature for diagnosis and prognosis in osteoarthritis." Scientific reports, 2023.
Pubmed:
37853066
DOI:
10.1038/s41598-023-44724-0
