PTAFR
A seven-transmembrane G-protein-coupled platelet-activating factor (PAF) receptor that localizes to lipid rafts and/or caveolae in the cell membrane is encoded by this gene. PAF, a phospholipid, is important for the development of tumors, angiogenesis, metastasis, and pro-inflammatory activities. Numerous signal transduction pathways, such as phospholipases C, D, and A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system, are stimulated when PAF binds to the PAF-receptor (PAFR). Cells rapidly lose their sensitivity after PAFR activation, and this refractory state is reliant on PAFR phosphorylation, internalization, and down-regulation.
| Full Name | Platelet activating factor receptor |
| Gene ID | Human: 5724 Mouse: 19204 Rat: 58949 Monkey: 716788 |
| UniProt ID | Human: P25105 Mouse: Q62035 Rat: P46002 Monkey: P35366 |
| Alternative Names | PAFR; platelet-activating factor receptor; PAF-R; PTAFR; Platelet activating factor receptor |
Product List
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Magic™ Human FLAG tagged PTAFR HEK293T Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX540]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PTAFR Target Family: Platelet-Activating Factor Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: HEK293T Assay Types: Calcium flux assay
Magic™ Human PTAFR U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay
[CAT#: S01YF-1222-KX104]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PTAFR Target Family: Platelet-Activating Factor Receptors Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
mProX™ Human PTAFR Stable Cell Line
[CAT#: S01YF-1023-PY324]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Platelet-activating Factor Family Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;HepG2;HCCLM3
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