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    Family stable cell lines Platelet-activating Factor Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human PTAFR Stable Cell Line

    [CAT#: S01YF-1023-PY324]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Host Cell Type:
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    Product Information

    Target Family
    Platelet-activating Factor Family
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;HepG2;HCCLM3
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    CNS Research
    Related Diseases
    Myringitis Bullosa Hemorrhagica;Anxiety
    Gene ID
    Human:5724
    UniProt ID
    Human:P25105

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Platelet-activating factor receptor (PTAFR) is a cell surface receptor that binds platelet-activating factor (PAF), a potent lipid mediator involved in various physiological processes, including inflammation, allergy, and cardiovascular functions. Recent research has highlighted the role of PTAFR in tumorigenesis, especially in the context of TP53/CDKN2A mutations. Moreover, PTAFR signaling has been implicated in fibrogenesis, suggesting its potential as a therapeutic target for fibrotic diseases.

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    FAQ

    chat Helen (Verified Customer)

    How does PTAF/PTAFR signaling influence gastroesophageal junction organoids? Jul 22 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Lipidomic profiling identified several platelet-activating factors (PTAFs) among the most up-regulated lipids in CRISPR-edited organoids. Abrogation of PTAF/PTAF receptor (PTAFR) signaling, either by siRNA knockdown or using a pharmacologic inhibitor, reduced proliferation and other proneoplastic changes in these organoids. Jul 22 2020

    chat Karen (Verified Customer)

    How does α-Hederin impact the metastasis of HCC cells in relation to PTAFR? Jan 01 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    α-Hederin can inhibit the platelet activating factor-induced metastasis of HCC cells. This is achieved by disrupting the PAF/PTAFR signaling pathway, which cascades to regulate STAT3/MMP-2 expression. Jan 01 2020

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    • Magic™ Human PTAFR U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay (CAT#: S01YF-1222-KX104)
    • mProX™ Human PTAFR Stable Cell Line (CAT#: S01YF-1023-PY324)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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