PRKCI
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
| Full Name | protein kinase C iota |
| Gene ID | Human: 5584 Mouse: 18759 Rat: 84006 Monkey: 574352 |
| UniProt ID | Human: P41743 Mouse: Q62074 Rat: F1M7Y5 |
| Alternative Names | PKCI; DXS1179E; nPKC-iota;protein kinase C iota type;PRKC-lambda/iota;aPKC-lambda/iota;atypical protein kinase C-lambda/iota |
Product List
Loading...
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: PKCι(PRKCI) Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;U2OS Assay Types: Biological assays
