mProX™ Human PRKCI Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PRKCI, which stands for protein kinase C iota, has various applications in different fields. In the field of mental health, PRKCI has been studied in relation to suicide. Research has shown that deaths by suicide are significantly increased during the week of the full moon, and PRKCI is one of the biomarkers predictive of death by suicide during this time. PRKCI is also associated with the peak hour of suicide and the peak month of suicide. In the field of cancer, PRKCI has been found to play a role in human cancer, particularly in pancreatic cancer and hepatocellular carcinoma. In pancreatic cancer, PRKCI is one of the differentially expressed genes that can be used for prognostic assessments. In hepatocellular carcinoma, a specific single nucleotide polymorphism (SNP) in PRKCI has been associated with an increased risk of HCC in the Pakistani population. Finally, PRKCI has also been studied in the context of hybridization in mammals, specifically in the russet ground squirrel. The study found that PRKCI contributes to the genetic variability of the squirrel and highlighted the importance of conservation measures for this species. Overall, PRKCI has implications in mental health, cancer, and evolutionary biology.