PRKCH
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction.
| Full Name | protein kinase C eta |
| Gene ID | Human: 5583 Mouse: 18755 Rat: 81749 Monkey: 704356 |
| UniProt ID | Human: P24723 Mouse: P23298 Rat: Q64617 |
| Alternative Names | PKCL; PKC-L; PRKCL; uORF2; nPKC-eta;protein kinase C eta type;Protein uPEP2 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Human primary glioma cells Assay Types: Biological assays
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: PKCη(PRKCH) Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
