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  • mProX™ Human PRKCH Stable Cell Line

    [CAT#: S01YF-1023-PY67]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1222-KX447 Magic™ Human PKCη(PRKCH) in Vitro Assay Human Kinase Assay

    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Human primary glioma cells
    Target Classification
    Kinase Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Stroke, Ischemic; Glioblastoma
    Gene ID
    Human:5583
    UniProt ID
    Human:P24723

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    PRKCH, also known as protein kinase C eta, has various applications in different fields. In the context of autism spectrum disorders (ASD), PRKCH is one of the risk genes for neurodevelopmental disorders and intellectual disabilities. DNA methylation profiling in both brain and blood tissues revealed that PRKCH is differentially methylated in these tissues, suggesting its involvement in altered gene regulation in the pathogenesis of ASD. In the field of dental research, mutations in PRKCH have been found to affect the splicing of amelogenin exon4, leading to the formation of a microRNA (miR-exon4) that plays a role in enamel and bone formation. PRKCH has also been implicated in cholesterol synthesis, where it is regulated by circRNAs and miRNAs. In glioma, PRKCH overexpression promotes tumorigenesis and influences glioma stem cell properties, making it a potential therapeutic target for gliomas. Additionally, PRKCH, along with other proteins such as PALLD, AKAP12, PDK4, and CHIT1, has been investigated for its role in the diagnosis and prognosis of neonatal sepsis. Overall, PRKCH has diverse applications in the fields of neurodevelopmental disorders, dental research, cholesterol synthesis, cancer, and neonatal sepsis.

    Protocols

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    Customer Reviews

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    FAQ

    chat Casey Miller (Verified Customer)

    What is the role of PRKCH in regulating the expression of transcription factor Runx2? Dec 02 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PRKCH expression negatively correlates with miR-exon4-mediated Runx2 regulation, impacting bone development. Dec 02 2020

    chat Alex Davis (Verified Customer)

    How does PRKCH expression relate to the prognosis of neonatal sepsis? May 22 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Elevated levels of PRKCH in serum are associated with neonatal sepsis, suggesting its potential as a biomarker for diagnosis and prognosis. May 22 2020
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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