PKN1
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
| Full Name | protein kinase N1 |
| Gene ID | Human: 5585 Mouse: 320795 Rat: 29355 Monkey: 718834 |
| UniProt ID | Human: Q16512 Mouse: P70268 Rat: Q63433 |
| Alternative Names | DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA;serine/threonine-protein kinase N1;protease-activated kinase 1;protein kinase C-like 1;protein kinase C-like PKN;protein kinase C-related kinase 1;protein kinase PKN-alpha;serine-threonine kinase N;serine/threonine protein kinase N |
Product List
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Magic™ Human PKN1 Assay
[CAT#: S01YF-1222-KX453]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: PKN1 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
mProX™ Human PKN1 Stable Cell Line
[CAT#: S01YF-1023-PY73]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;A172;U87 Assay Types: Biological assays
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