mProX™ Human PKN1 Stable Cell Line

[CAT#: S01YF-1023-PY73]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX453	Magic™ Human PKN1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;A172;U87

Target Classification

Kinase Cell Lines

Target Research Area

CNS Research;Metabolic Research

Related Diseases

Mevalonic Aciduria; Malignant Acrospiroma

Gene ID

Human:5585

UniProt ID

Human:Q16512

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PKN1, a serine/threonine protein kinase, has various applications in different fields. In the context of phagocytes, PKN1 is involved in the positive regulation of oligomeric pyrin, which triggers inflammasome assembly in response to bacterial toxins. Dysregulation of pyrin is associated with autoinflammatory diseases such as Familial Mediterranean Fever (FMF). PKN1 is also implicated in the pathogenesis of gliomas, where its upregulation promotes tumor growth and metastasis. In rectal neuroendocrine neoplasms, PKN1 mutations are found in low-grade tumors, helping to distinguish them from high-grade tumors. Additionally, PKN1 plays a role in adipocyte differentiation and glucose metabolism, and its decreased activation is associated with insulin resistance in obesity and type 2 diabetes. Overall, PKN1 is a key player in various cellular processes and has potential as a therapeutic target in different diseases.

Protocols

Please visit our protocols page.

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FAQ

chat Casey Williams (Verified Customer)

What is the role of PKN1 in prostate cancer? Apr 11 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PKN1 is overexpressed in prostate cancer and may serve as a potential biomarker for the disease, aiding in the development of personalized therapeutic approaches. Apr 11 2022

chat Morgan Johnson (Verified Customer)

How does PKN1 affect endometrial cancer prognosis? May 30 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Higher expression levels of PKN1 in endometrial cancer patients are associated with poor prognosis, suggesting its potential as a prognostic marker. May 30 2021

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