PIM1
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
| Full Name | Pim-1 proto-oncogene, serine/threonine kinase |
| Gene ID | Human: 5292 Mouse: 18712 Rat: 24649 Monkey: 114677751 |
| UniProt ID | Human: P11309 Mouse: P06803 Rat: P26794 |
| Alternative Names | PIM;serine/threonine-protein kinase pim-1;Oncogene PIM1;pim-1 oncogene (proviral integration site 1);proto-oncogene serine/threonine-protein kinase pim-1 |
Product List
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Magic™ Human PIM1 BaF3 Cell Line
[CAT#: S01YF-1222-KX798]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: PIM1 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
mProX™ Human PIM1 Stable Cell Line
[CAT#: S01YF-1023-PY55]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;ACC-MESO-1;CRL-5915
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