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    mProX™ Human PIM1 Stable Cell Line

    [CAT#: S01YF-1023-PY55]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Kinase Cell Lines

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    Product Information

    Target Family
    Kinases/Enzyme
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;ACC-MESO-1;CRL-5915
    Target Classification
    Kinase Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Primary Central Nervous System Lymphoma; Polyploidy
    Gene ID
    Human:5292
    UniProt ID
    Human:P11309

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    PIM1 has various applications in different areas. In liver cancer, PIM1 is involved in the growth of liver cancer cells and affects the transcriptional and translational abilities of multiple genes, as well as signaling pathways related to liver cancer. In Saccharomyces cerevisiae, PIM1 is essential for maintaining low levels of the mitochondrial HMG-box protein Cim1, which negatively regulates mtDNA copy number. In lower extremity deep venous thrombosis, PIM1 is part of the PIM1/FOXO3a axis and is involved in regulating apoptosis and angiogenesis. In the context of pathogen infection, PIM1 interacts with GBP1 to limit self-damage and protect against pathogen infection. Lastly, in colorectal cancer, PIM1 enhances the radiosensitivity of BRAF-mutated CRC cells by affecting the cell cycle, DNA damage, and tumor apoptosis. Overall, PIM1 plays a role in cancer growth, mitochondrial function, thrombosis, immune response, and radiotherapy sensitivity.

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    FAQ

    chat Jordan Smith (Verified Customer)

    How does PIM1 mutation affect diffuse large B-cell lymphoma? Apr 08 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    PIM1 genetic alterations in diffuse large B-cell lymphoma are associated with distinct molecular profiles, phenotypes, and drug responses, highlighting its role as a personalized therapeutic target. Apr 08 2022

    chat Skyler Davis (Verified Customer)

    Can natural compounds inhibit PIM1 kinase for cancer treatment? Jan 05 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Certain phytoconstituents have been identified as potent inhibitors of PIM1 kinase, suggesting their potential in anticancer drug discovery. Jan 05 2022

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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