PAK4
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
| Full Name | p21 (RAC1) activated kinase 4 |
| Gene ID | Human: 10298 Mouse: 70584 Rat: 292756 Monkey: 696676 |
| UniProt ID | Human: O96013 Mouse: Q8BTW9 Rat: B5DF62 |
| Alternative Names | serine/threonine-protein kinase PAK 4;p21 protein (Cdc42/Rac)-activated kinase 4;p21(CDKN1A)-activated kinase 4;protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs |
Product List
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mProX™ Human PAK4 Stable Cell Line
[CAT#: S01YF-1023-PY43]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;HeLa
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